I don't really have an issue other then the slow retainers and such.
Ok its not super responsive but then its not as FPS so its not a game braking issues.

The client server side is the main thing (from what little i bothered to read) that could be an issue. I understand thier intention but i dont think its really needed, all the anti RTM ideas they have we know about serve to annoy the players as much as do anything i would think.
No fullscreen windowed and alt-tab kills the game so some are forced to use windower or other such programs.
Not being able to run my 2nd client from the same Pc is my main annoyance.

and many people are at least aware of bot programs or the many gaming keyboard you can virtually bot with anyway.
(Gaa fail, just realised my auto correct has been putting "key bored" every time till.. thats well... meh! anwyay)

To the OP:
I doubt that SE are not aware or working on improvements, we could use a technical round up, but the only guys that do that in a mmo I'm aware off is CCP, so I wouldn't hold my breath in SE changing the customer relations to that level.