Dang, the rare relevant thread necro, spotted in the wild. It's like seeing a forum unicorn!

Snark aside, no, it doesn't really apply any longer. Nvidia's current drivers default to "auto" for multithreaded behavior -- i.e., if it is possible to function multithreaded, it will, otherwise it falls back to the old single-threaded behavior. Setting it to explicitly multithreaded will do functionally nothing (that I'm aware of) any longer.

And the other portion was only relevant inasmuch as it let you disable a compatibility mode that was enabled on a specific Intel chipset. If you do happen to have an Intel computer dating to between... uh... like 2009 and maybe mid-to-late-ish 2013? ...then it might be relevant, but any computer that isn't about 9+ years old shouldn't need that tweak. (Honestly, I don't even know if that's still even as a setting in recent drivers. Though it might be; I have not gone looking in any settings not exposed in the Nvidia Control Panel for... well, a while. For the insides of the Nvidia drivers are dark, and full of terrors.)