From looking at it, it looks like using both is more helpful for the big jump starting off. Where you need to feed a lot of fruit and if you do too much of one you will push the value of that color to far off for the rest to work correctly.
The calculator says they need 1 plum, 2 valfruit and 3 pineapples.
doing this you would hit (51 red) (49 green) & (47 blue) which is off by +4 / +2 / +8

but if you mess around with the spread sheet you can use 2 pineapples and you would hit (41 red) (49 green) & (37 blue) which is off by -6 / +2 / -2

Hit value was gathered from the spreadsheet as well as how far off of the target color stated by the spreadsheet.
I think the spreadsheet is better used by itself if you are only trying to micro move.