Most of my cooldowns/Wrath-related skills are clicked because with a 2.0-2.5s GCD I don't really have a problem manually clicking them. But, for the ones I have keybound (don't have a SS b/c PS4):

1-3: Heavy Swing -> Skull Sunder -> Butcher's Block
4: Tomahawk
5: Overpower
6: Flash
F1/F2/F3: Maim -> Storm's Eye -> Storm's Path
F: Brutal Swing
R: Provoke

Rest are the ones I click manually, though I think it's better to have your Wrath abilities keybound, just never bothered personally. IR -> Berserk -> Second Wind should be near eachother, IB -> SC -> Unchained -> Infuriate I have on my third horizontal hotbar seperate from everything else. My setup is pretty basic and wonky but it's never caused me any problems. One setup I would recommend for BB/SE/SP combo is:

Q: Heavy Swing
E: Maim
1-4: Skull Sunder / Butcher's Block / Storm's Eye / Storm's Path

I'm way too used to my current setup, but this is how I would do it if I wasn't.