Anyway to set 2 different button configurations for the same job?

[Bixby]

You can swap sets of hotbars with /hotbar (for keyboard) or /chotbar (for gamepad) copy.

For example, if you're using hotbars 1-3 on DRG, with 4-6 being the set you're not currently using (so you've currently got your PvP stuff on 1-3 and PvE stuff on 4-6), and Miner bar #4 not in use (used as swap space):

/hotbar copy DRG 1 MIN 4
/hotbar copy DRG 4 DRG 1
/hotbar copy MIN 4 DRG 4
/hotbar copy DRG 2 MIN 4
/hotbar copy DRG 5 DRG 2
/hotbar copy MIN 4 DRG 5
/hotbar copy DRG 3 MIN 4
/hotbar copy DRG 6 DRG 3
/hotbar copy MIN 4 DRG 6

Stick all that on a macro somewhere. Use that macro to swap back and forth between PvP and PvE bars.

If you want to do things with shared bars, "share" takes the place of a job name (e.g. /hotbar copy share 7 DRG 4). And "current" is always your current job, so if you set things up the same way for multiple jobs, you only need one macro (e.g. /hotbar copy current 1 MIN 4).