Playing with a gamepad I use macros almost exclusivly, especially for my mnk. Since certain skills can only be used in certain stances, i macro together the flank/behind skills so they only use two icons instead of 4, and also use them to autoweave in my dps buffs. Is this optimal? no, but it sure beats the headache I get when trying to cycle through multiple bars in only one direction.

I also use them for making HQ recipes, and more recently made macros to auto-summon my minions each time I change jobs.