For those worried about accidental discarding... it can be defaulted unbound.

But an option to Ctrl+RClick items to insta-discard would be so nice with the auto-looting system...

Having to manually 3-click every single piece of junk that drops into our inventory is irritating as heck!

Or perhaps an option in settings to not pickup drops below a certain ilvl (selectable with slider) or non-hq.