From my personal experience, animation lock (however slight it will be) will prevent the skills from going out later than it should. I've had better mileage from using the skill manually and weaving it inbetween my GCD than macroing it to my heavy/straight shots. It's also nice to have the freedom of using BL/ME on selective targets. That's just me though.

Since there's really no buff or visual indicator to BL resets from DoTs, what I did was took a hotbar, enlarged it absurdly and BL on the screen where I can easily see it (similar to a focus bar) just to keep track of it's cooldown. Sorta like this http://puu.sh/cyXTw/33978f3cee.png .

Eitherway, switching to macros is going to take some time getting used to. I've been weaving it since I capped, tried out the macro and didn't really like it, and I'm pulling more than my weight in dps so I don't have any problems.