Most likely by the time 3.0 comes out Relics will be i135 and BiS again, we just have to wait for the quests to drop. Hell, if the "Ultimate weapon" comment of Yoshi-P's is taken as a lot do the Relic could be i140.

As others have said though, Nexus will be BiS for the vast majority of the game's population for a while given Final Coil's difficulty.