Energy Drain with Raging Strikes (180 Potency) is still less than a Fester even if it crits (270 Potency). So no, do not use Energy Drain even with Raging Strikes being up.IMO best opener is this. Also make sure pet is isnt on obey, if garuda uses her aerial slash on a single target you are losing dps.
make sure you have 3 stacks of AF, and AF skill ready
Raging Strikes -> X-Potion of Intelligence -> Bio II (Start precasting it when you see your tank about to engage) -> Miasma (Start moving toward the boss at 0.5 left on the cast) -> Bio -> Fester (when Bio applies) -> Miasma II -> Potent Poison Potion -> Contagion + Swiftcast -> Shadow Flare -> Rouse -> Ruin II -> Spur -> Ruin II -> Fester -> Ruin II -> Enkindle -> Ruin -> Ruin -> Ruin II -> Fester -> Ruin II -> Aetherflow.
It would be this but weave in Energy drain with RS up, pointless sitting on stacks with RS up
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