Tab Targeting.

[Souljacker]

It's worse on PC. You can be literally facing, right in front of, the monster you want to target and it will still target something random to your left, far in the back. I play a mix of controller and keyboard\mouse, depending what I am doing, and I really wish I could get the targeting predictability of the controller with the UI control of the keyboard\mouse. Perhaps the expectation wouldn't be there if there weren't targeting options in the menu - but there are and they just don't work.

PC has an option to auto-face what you are attacking.

And it's something that no one should get used to. If you want to do any sort of raiding, it's best to just leave this one ticked off. Even with very careful planning of abilities, that one unexpected twitch of a finger can have you running back into the fire.