As everybody has said, using maccros will lower your dps (with respect to a perfect one). However I think you can still put some of them together and limit the dps loss you will have. The maccros I was thinking to are
- Mercy Stoke with Twin or Snap or BS or True. Only one of them (to limit the dps loss) but spam it!
- Blood for blood with Inner Release
- All your defensive cooldowns together
I don't use maccro so I am not sure it works as I think though.