hmm how about this:

map your hotbar 1 to: 1,2,3,4,5,q,e,r,f,v,c
hotbar 2 to alt + 1,2,3,4,5,q,e,r,f,v,c
hotbar 3 to ctrl+ 1,2,3,4,5,q,e,r,f,v,c

target lock to capslock

everything you do is on your left hand.

i manage to do just fine. i don't use a gaming mouse because mine broke down and im too much of a cheap guy to buy another so i use a generic mouse instead.

also i can do content with one hand, and pick my nose with the other. its pretty rad.