Keybinding...

[Dyne_Fellpool]

honestly, the GCD is so long in this game that clickers aren't really at any disadvantage. plenty of time to move that cursor around, even to hit off-GCD stuff asap.

Of course that doesnt answer the question in the OP, but plenty of people have already done that.

[TouchandFeel]

My setup is as follows:

Razer Naga 2014 Mouse
- 1 to 0,-,+ keys assigned to side 1-12 keys on mouse and used for basic abilities for ability bar 1.
- Scroll-wheel middle click used for Target Focus.
- Scroll wheel left/right click used for Tab/alt+Tab targeting.

Razer Tartarus Game Pad
- Joystick used for movement (forward, back, strafe left/right, I steer with the mouse).
- Thumb paddle button (the big one beneath the joystick) for jump.
- Other thumb button for auto-run.
- Keys 02-05, 07-10, 12-15 (12 total) are used for abilites and are automatically set up to function as shift+1, shift+2, etc. through the Razer software.
- Key 01 is Esc for quickly exiting out of or closing things.
- Key 06 and Key 11 are modifier keys, 06 = Ctrl and 11 = Alt, so then if I hold one of those down and hit one of the other keys on the game pad it overrides the shift modifier built in and changes it from something like shift+1 to ctrl+1.

For chat and stuff like that I just use a basic keyboard.

With this setup I can easily fire off abilities from all four of my combat ability slotted bars without ever lifting up my hands and very little movement, which results in faster reaction times (once you get used to the setup) as well as less finger fatigue from long sessions of playing.

If you are not a fan of Razer you could probably do a very similar setup with the Logitech G600 MMO mouse and Logitech G13 Game Pad.

While I have heard many people say they have had durability issues with the Razer accessories, I have had none with the multiple different mice I have had over the years and I still have all of them in perfect working order going all the way back to a 1st gen Diamondback that is probably over 7 years old now. Maybe I got lucky or maybe it is because I use a very light touch hybrid finger/claw grip. As for which company and which accessories are best for you, that all depends. Do your research and if you can go to a brick n' mortar store to actually get your hands on different ones to test out the feel.