1 2 3 4 5

Shift + 1 2 3 4 5 a q w e r t a s d f g c v b

Those should cover all you need really, those combinations are the most "natural" that doesn't require my fingers to bend unnaturally like alt modifiers. Ctrl modifiers work similar with shift too!

I've used this in many mmos, from casual based to end game based, crafting, gathering, pretty mych everything.