Well keep in mind that most any setup will take practice to get used to, just have to try things out and see what works best for you ^_^.

That said, I started using QERFC as my hotkeys, along with their shift and ctrl modified versions. There's also the middle and two side mouse buttons, as well as their shift/ctrl modifiers as well. It's not enough keys to completely cover three full hotbars, but it's enough for the majority of abilities, just leaving cooldowns to be clicked generally.