All my most important abilities go on vanilla/ctrl/alt+1234. Situationals go on 567890-=, rarer situationals are ctrl/alt+890-=, extremely rare and non-time sensitive are stuck on ctrl/alt+567. It's kind of a crap shoot whether I press the hotkey for rares/extremely rares, and might click them depending on the other movements of my hand at the time. As an aside, I've also disabled all key combos involving wasd to prevent failures of movement or ability use when dodging and trying to do things at the same time.