I don't believe it has anything to do with automatic game detection, on the PS4 anyway. I have the PC and PS4 versions and I used a G600 on both. Before 2.3, to get the side mouse buttons to do Ctrl+1,Ctrl+2,etc. on the PS4, I had to program that mouse on my PC and set it to on-board memory. When I then plugged it into my PS4, the side buttons worked as programmed. Since 2.3, even with these settings, all I get is just the number, not Ctrl+<number>. Since mouse support is implemented per game on the PS4, my guess is that SE changed something and isn't accepting the programmed input anymore.