I don't care who somebody is IRL. If we're interacting in a game, then it's who they are in the game that counts. Male characters get male pronouns and female characters get female pronouns. Makes everything easy and nobody can be offended by it. People playing characters of the opposite gender as themselves obviously wouldn't be doing so if they objected to being referred to that way.

(On the forums, by default you get the pronouns of the character in your avatar image, though if your RL gender is mentioned I'll switch to those pronouns. In game, I generally won't switch pronouns just because someone mentioned their RL gender, but will if they do so explicitly to specify that they prefer going by RL pronouns rather than IG ones.)