I have been playing FF11 on PC before I started playing this game (I never played any other MMORPG besides these two games)
I completely altered the HUD to the like of FF11 style, using legacy settings, key bindings similar to that of FF11. I use [ and ] to switch between targets, ASDW to move, all spells/skills fit into the two default bars with a few additional keys binded with Backspace, \, and `.
I never ever used the mouse when playing FF11, however, that doesn't change much when playing this game with the ONLY EXCEPTIONS I have to use my mouse when I cast Freeze, Limit Break, and navigating on my Chocobo.

My HUD is something like this:

http://na.finalfantasyxiv.com/lodest...7/blog/531400/

http://na.finalfantasyxiv.com/lodest...7/blog/855419/

Those are old screenshots. I don't have any recent screenshots on my laptop as I'm at work right now. But you probably get the idea.
I simply use shift + up/down to switch hotbars when I need to change jobs fast. My settings are pretty much 99% mouse-free.