My current/planned binds are as follows using a 6-extra-buttons mouse:

Hotbar 1:
1 - True Thrust
2 - Vorpal Thrust
3 - Full Thrust
4 - Heavy Thrust
5 - Ring of Thorns
6 - Phlebotomize
7 - Doom Spike
Q - Impulse Drive (Replaces 8)
E - Disembowel (Replaces 9)
R - Chaos Thrust (Replaces 0)

Hotbar 2
CTRL+1 - Invigorate
CTRL+2 - Spineshatter Dive
CTRL+3 - Dragonfire Dive
CTRL+= - Elusive Jump

Hotbar 10 (vertical, on the right)
M1 - Leg Sweep
M2 - Internal Release
M3 - Blood for Blood
M4 - Power Surge
M5 - Jump
M6 - Life Surge

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I have my Hotbars set up so that the GCD skills are on the main hotbar, grouped by combo (and Doom Spike for AoE). The Off-GCDs that are used in a general rotation are on the side so I can glance at them easier, and are bound to mouse buttons. Lastly, the Jumps (aside from the basic Jump) are situational skills so they are shunted to a second Hotbar. Ideally, I'd like to get Elusive Jump onto an easier "oh shit" button for dodging mob/boss AoEs but haven't figured that out yet.