I would recommend only combining Misery's End/Bloodletter with a single Skill.
The reason for that is because using macros disables the command queue.
That means you will lower your potential dps by using macros with skills that are on the global cooldown.
To show you what I mean, put Heavy Shot from your skills list directly onto your hotbar.
Cast it, then hit the button again about a second before the GCD actually looks ready.
You will see that it automatically goes off the exact instant your GCD is ready. Cast it several more times in a row and notice how fluid and fast it appears.
Now make a macro for Heavy Shot: /ac "Heavy Shot" <t> and put that macro on your bar. Now try the same thing, casting it several times in a row.
You will notice that the server no longer lets you queue that skill up. You have to wait until AFTER the GCD shows as ready before you can hit the button.
It will almost certainly feel more clunky and "slower".
Because the macro can't utilize the command queue, you lose fractions of a second every single time you use the skill.
Those fractions add up over the course of a fight, resulting in noticeably lower dps output.
Because of the command queue, it's best to avoid using macros together with skills that are on the global cooldown wherever possible.
HOWEVER;
Venomous bite accounts for less than 10% of the total skill casts you'll execute over the course of a fight, so the dps loss from not utilizing the command queue with only this 1 skill will be nearly nonexistent.
So if you want the convenience of being able to re-use one of your on global skills for weaving, then use Straight Shot, Windbite, and Heavy Shot by themselves, but then use this macro for Venomous Bite:
/micon "Venomous Bite"
/ac "Venmomous Bite" <t>
/ac "Misery's End" <t>
/ac "Bloodletter" <t>
You can also macro your buffs together since they are all off-globals and you will be weaving them, so the command queue doesn't matter.