Just a note, during combat I always play left-handed. Assuming you have have your primary and secondary hotbars set up you should be able to maneuver and access all your skills fine. Changing the camera angle is the only fail point.

Follow up note: I'm a southpaw, so that may influence my view point.

I didn't see it mentioned so try to get into parties for the fates. That will make it easier to gold. The second and third fates are single big monster. The fourth fate is 2 part - the first part is multiple mobs, the second part is single big mob. The first part of the fourth fate is optional but I think it has to succeed for the second part to show up.