Quote Originally Posted by Bardo View Post
Remember that if you put skills that are on the global cooldown into a macro, you disable the command queue.
That means you lose about a quarter of a second (more or less depending on your latency) every time you use that macro.
So if you're trying to maximize your dps, it's best to use macros for off-global abilities only.
Basically this. Macro skills ruin command queueing , so you lose time on each skill cast