I have my set up as follows;

ASDW to move on legacy controls.

Q targets left.
E targets right.
Spacebar targets/interacts with the nearest target(s).

Alt Spacebar is jump (since I hardly need to do it)

2 is auto run.
Tab is a macro to target <f>

ctrl alt W is focus target


now, to target party members, i either use F1-F8 or use R to cycle up, or F to cycle down.
To cycle down the enemy list Shift R or F.

Cycling left and right through the alliance members is Shift Q or E.

That leaves me with using the num pad for abilities, along with the middle section for abilities (insert, home, page up/down, delete, end)

I also hit Alt with the num pad for more options.

then anything that requires mouse targeting, i use the middle mouse button click in. (along with alt, shift, and ctrl if need be)

Other than mouse ground targeting, i never touch the mouse. i also use the arrow keys to move the camera. (fingers on num pad, thumb touches the arrows to look and attack)