I think a good PC has some advantages over the PS3 system, due to networking and just better hardware overall might make things run smoother better/better looking whatever. Also PC has some advatanges that PS3 does not (Focus Target for example).

However, the differences are not enough to be truely significant and impede someone from completing content. BUT, they might hinder some individuals enough to cause this, but this happens on an individual basis.

To some players it'll be easier, more comfortable and overall better to play with a controller over mouse and keyboard, getting advantage by it rather than being hindered by the other (and the opposite is also true, maybe more often than not). Some people might not be able to do certain things as well without the focus target.

But then again, this is per individual basis. The PS3 limitations are not in any way hindering the gameplay enough (in these cases, we can all agree for example that Odin' is clearly way better and easier to do on a PC) to prevent players from completing content.

So, in short, it depends on who is behind the controller/mouse+keyboard.

PS3 is not any more of a hindrance than any other factor in play (latency/random lag, derp skills, etc.).