As a PS3 player (can also play on PC, though sluggishly because of hardware), there's nothing inherently debilitating our ability to play effectively. That said, I haven't done T5 so yada yada, you get the point.

I've heard it's because we use controllers (which many PC players do, though the majority likely use mouse/kb), but I'd argue it has nothing to do with it, the only thing inhibiting some skill use is switching to the wrong cross bar on accident and the L1/LB auto run when adjusting the camera acting up since 2.1 released. Though you can as easily accidentally switch to the wrong bar when using multiple hotbars on a KB as well.

Hardware-wise the PS3 is perfectly capable of playing the game, it has frame rate limits on other player models and whatnot, yes, but the game runs smooth. Unless Twintania is a 24-man fight with 10+ mobs on screen in a large, detailed area (which I know it isn't), the PS3 has no issue.