Take the time to look at the targeting filters and other options like Darkkos mentioned. If you don't know about "square + arrow," you haven't taken the time to customize the options.
I'm on ps3 and have only made very minor changes, and targeting is a breeze now. Don't it has to be redone if you haven't taken the time to customize the generous targeting system that was already implemented.

I agree with Lordfurious in where there should be something implemented like "custom sets" that you could save and select depending on what role you want to use.