You should never be in Defiance as OT. You should be out of Defiance alternating SE and SP combos.
Yes, it is. However, you will never need it for enmity in 2.1 with the huge modifiers we have. Definitely more useful for single-target situations, but those are also trivial for holding aggro unless the OT doesn't know what to do and sits in Defiance spamming Butcher's Block.
Best to look at it in terms of DPS boost. You should use Unchained -> Berserk -> Inner Release on things like Titan heart phase to add to DPS checks, and occasionally early on when you have the cooldown time available between DPS checks.
//EDIT: Also,
I believe we will have to actually test the enmity modifiers before we can know for sure. It's possible that Steel Cyclone has a higher or lower modifier than Overpower.



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