There are ways to get 100% HQ from those synths with NQ materials, so if you do get it crafted, get it from someone who can do that.
The only place where you need 4k+ HP is turn 5 and Twintania (well for now, we'll see what 2.1 brings). You shouldn't worry about it at all until you've beaten 1-4 in Coil. And you can do those with relic and full darklight and carry your weight.The Vitality is really the main reason I'm looking into this because lately I feel like a lot of parties request you to have 4k HP and even though my main gear is all ilevel70 and I have a relic +0, im at 3500 HP :/