There are a lot of different ways to handle the snakes. We still go with staggering out the Disseminate debuffs to ramp up DPS on Asclepius; when he gets hit by LB2 along with the second set of Hygieia, I believe he is already at around 60-65% (sometimes lower, sometimes a lot lower). The timing generally ends up being: first Hygieia dies ASAP, second Hygieia dies as first stack of Disseminate is <10 seconds (usually around the first or second divebomb in the second set of divebombs), third Hygieia dies immediately almost after getting into position (LB2 drops it very low then it dies shortly thereafter), fourth Hygieia dies, kill Asclepius. When we stagger out the second Hygieia kill to stretch out Disseminate, we have one DPS (usually a BLM due to Manawall) watch the timing and make sure it dies.

What % is Asclepius at when you bring him and all of the Hygieia together for LB3?