Misinformation so far, unfortunately.

1. You do not want to use Berserk and Internal Release on CD. You want to use them together, in almost every possible scenario.

2. Do not touch Defiance. Going into Defiance, using Infuriate so you can get that fatty Inner Beast off is more detrimental to your DPS than anything. When you go into Defiance, you are forced to stay in it for 10 seconds. All DPS gain you will get from being able to use Inner Beast you will completely lose from being forced to sit in Defiance for 10 seconds.

Everything else mentioned in this thread is correct. Spam Storms Eye combo until threat allows you to weave in Butchers Block. Never let Maim fall, do not clip Fracture and don't let Fracture fall off.