My bindings are quite different but I´m using similar buttons. e.g. I do have Lustrate on my mousewheel. This grants me 100% freedom of movement. Leeches is on F for fast reacting. Combinations I do use quite often but are on long CD´s are near each other or do not interfer. e.g. Swiftcast "C" + Succor "MB-Thumb" or Shaddowflare "V". I dont´t use 6-0 (Basicly I do but for potions which I rarely use) I scatterd the dps arround in semi-good reach Shift 1-3, G, T, 1,3,4.