Quote Originally Posted by DxWings View Post
3. Because Misery's End, and Bloodletter does not trigger GCD, you're locked into their animation(~1.5s) til you can start using another skill.
Well, this isn't the overriding issue. This is solved by simply placing the GCD ability first in the macro -- you are then strongly mitigating (although not eliminating) the scenario where the oGCD animation delays your GCD.

The core problem is that the ability queue itself breaks for the GCD ability, causing a consistent and pervasive 0.1-.5s delay every single GCD. In other words, a pure 5-15% DPS loss.