I switched my movement keys to the number pad. I can move around with my right hand or reach over and target things with my mouse while keeping my left hand on my hotbars/macros at all times so I can cast immediately. I use the F keys to target players before pressing my hotkeys, which are just set to <t>. I have one row set to just the numbers, one row set to Alt+[number], and one row set to Ctrl+[number]. The Ctrl row is less common things, like Raise, Protect, and food, and I have it as a vertical row on the far right side of my screen.