Macroing skills via specific targets is a terrible way to do things. It's over complicating your playstyle and I'm fairly certain gets pretty frustrating and out of control pretty quick. Macros let you do a lot in the game, but just because it's possible doesn't mean you should.

Clicking on individuals seemed too slow to me, so I tried reorganizing my UI and putting in <mo> and <tt> macros. My group window is right next to my onscreen avatar. I keep hostile creatures targeted most of the time (except when I need to heal myself occasionally). <mo> macros will allow you to heal people via your group window without actually having to target them. Just place your mouse over their name and click your key bound button to cure/dispel/resurrect/etc. Works out for me very well and if you haven't tried it yourself, I'd suggest you give it a shot.