I get it a little bit in Limsa Lominsa when i first log in but besides that this game runs pretty flawless on my system.

Self Built Custom PC
CPU: Intel Core i5 760 Quad Core @ stock speed
Mobo: EVGA P55 SLi E655 with E72 bio's
RAM: 4GB G.Skill DDR3 1333MHz
HD: Seagate 7200RPM 32mb cache 1TB SATA II 3gb/s HD
GPU: Single EVGA nVidia 560 GTX Ti FPB 1024MB GDDR5 OC'd to 925Mhz
PSU: XFX Black Edition 850W Modular PSU

GPU Usage hits 99%
CPU usage hits about 50% all four cores

Highest graphics settings with 4XMSAA with Depth of field Average around 30-40FPS In and out of towns