Both my wife and I have fairly high end systems and can run most games at the highest settings, but no matter what settings we choose for this game we get a lot of "stuttering" particularly in towns. I notice a lot of hard drive caching going on during those times, I am not sure if its related. it's really annoying and takes away from the immersion in the game.

But just to give you an idea
AMD 955 quad core
4GB of DD3 1600MHz RAM
ATI 5770 graphics card 1GB of RAM

my wife has
Intel Core i7-720QM 1.6GHz Quad-Core Processor
8GB of DDR3 1066MHz Memory
ATI Radeon HD 5870 graphics (1GB DDR5 discrete graphics memory