Enmity problems!!!

[Vortok]

Since you seem to be a Warrior, I've found this to be a very serviceable opener:

Blood Bath > Tomahawk target 1 while running up > Berserk > Flash (threat based on Attack Power, last I knew). 2 GCDs activating Maim. Overpower x2, Butcher's Block combo. Good dps (that are blowing cooldowns as well + tunneling the primary target from the word go) will often get close to pulling about when you hit the single target threat moves and the Butcher's Block should solidify your threat.

Flash once during the Pacify from Berserk because it's free threat. Everything is now glued to you. As long as you tab around to check for multi dot/healer threat it should be pretty smooth sailing.

Without Berserk available you can just do a second Butcher's combo and will have to pay slightly more attention to multi target threat. Could also move one of the 2 Overpowers to after the first BB if worried about threat on target 1.