I've been using the new targeting system exactly like it was before. If you guys remember making macros on FFXI, there was a command <st> for selecting targets after choosing a spell. The default system on here reminds me of that, when you choose a spell you get a subtarget so you can stay locked onto a mob while healing party members. You cannot target mobs with the subtarget for a cure spell, and you cant target party members in the subtarget for nukes. This is how i get around the UP/DOWN issue.