In endgame raiding, usually, clicking abilities and/or not using mouse-over macros tends to be looked down on. IE Pressing a key is WAY faster than positioning the mouse and clicking (especially when you have to use the mouse to target or hover), you lose a ton of efficiency...but that's with games which don't have a 2.5 second GCD, lol. Obviously you can click to your heart's content in this game since you have plenty of time between abilities, though you'd probably lose some reaction speed when having to move. Next we should find those keyboard turners :-P