I play on a PC, and though I tried switching to keyboard+mouse, my left hand just hated the modifier key abuse and how it has to go all over the numeric keys. The lack of a Dvorak layout setup is also annoying. No thank you, back to (PS3 in xinput emulation) controller. It's not like you take more than 1/2 second to pick your next skill/spell anyway, and you can't use them faster than that on a keyboard either.
Here's what I do for SMN:

The "Spur" icon there is the only macro:
Code:
/micon Spur
/ac Rouse <0>
/ac Spur <0>

Though I'll admit I almost never remember to use Miasma II. Tri-Disaster is there for... completeness I guess, never found any use for it; terrible damage and long cast time. Rouse is there just so I can check its cooldown separately from the macro, Aetherflow for its cooldown while I'm spamming Ruin.

Set 3 is due to habit since that's where I do the fairy summoning as SCH. This set-up is actually quite different from my SCH setup, so I have some muscle memory woes shortly between switching between the jobs, but I find their respective setups to work well enough.
On the character configuration, then, I disable the pet bar and use the set customizations:

Switching between sets 1 and 2 then is just a matter of tapping RB; it won't take me through other less relevant sets just because they exist. Also of note: NO Toggle / Mixed hotbars. They make you lazy about using the triggers, and mixed mode tends to do toggles when you don't mean it to.
Sprint / Teleport / Return / Mount are on my Set 8, though you can just put them on whichever shared set you think you'll remember to use. You can also set it as the only set in the set customization (not the one while weapon is drawn); that way, closing the book gets you ready to do teleports et al. I also disable the auto-sheathe; if I want to sheathe, I can just press the left stick. The ACN jobs look cooler with the book open anyway