Manipulation

[Roth_Trailfinder]

Waste Not does make Manipulation redundant. It seems to be a slightly better option than Masters Mend if Waste Not isn't available to you. If you have ran all craft classes to 15 though it gets put in the dust bin.

I use Waste Not and Manipulation in the same 40 Durability synths all the time.

Inner Quiet
Steady Hand (2)
Waste Not
Hasty Touch
Hasty Touch
Hasty Touch
Hasty Touch
If it takes 2 Synthesis actions, Synthesis here, if only one, Hasty Touch.
Manipulation
Steady Hand (2)
Waste Not
Hasty Touch
Hasty Touch
Hasty Touch
Hasty Touch
Best Touch I've got CP for
Synthesis

I won't use Tricks of the Trade while I've got Steady Hand (2) going, simply because doing so either wastes one charge of Waste Not, or it throws Steady Hand (2) and Waste Not out of synch. At 40, I've got enough CP that I can throw a Basic touch at the end without any Tricks uses.

As long as you know what you are doing, Waste Not and Manipulation complement each other, they do not replace one another.