Just started the game with a new rig and would like some tips on getting best graphical output/performance. With goal of 50-60 fps what is the best settings I can handle?

Quick specs:
-Intel i5 2500k (not OC'd yet, goal is a stable 4.0ghz)
-Nvidia Geforce GTX 560 TI Maximum Graphics Edition 1gb (it is factory OC's to 900 - no plans to push that up)
-Currently 4gb 1300 ram but 4 more gigs being shipped for total of 8gb 1300
-24inch ASUS LCD monitor 2ms 1920x1080

PS. Not too computer savvy so might need dumb-person speak if I need to 'force' things or load this or that third party program to get a specific setting.

Thanks in advance!