I have 2 5850s in CrossfireX and use Radeon Pro. I deleted my FFXIV Radeon Pro Profile when AMD released the FFXIV profile - I just keep Radeon Pro enabled as it unlocks some extra features on my cards the standard drivers don't. I also use Game Booster (Formally the free edition but I spend the 15 € on the Pro Edition). I'd really recommend you try the free edition, I noticed a big boost in reactive performance.

I now dance around everywhere at 55-60 fps and have next to 0 lag in response from my Gamepad, even in a busy Ul'dah and everything looks sweet. I have AA x4 DoF on, AO off (of course) and everything cranked up to max.