After some research I've found that comfort zone is especially useful in these synths, which will net you another 60+ durability to work with, enabling a waste not or another manipulation if need be. This will be the next cross-class skill I will be picking up.

Reclaim is an unsung hero here. If you do have those synths where your durability has been shot due to hasty touch failures, you can always reclaim for the 90% chance of recovering materials. This is especially prevalent when you are doing HQ 2 star synths which can run you 500k+ in mats