if you're not using a keyboard you're not going to be as effective. end of story. choose whatever you want, it really doesn't matter. but if you are a min/maxer, use a keyboard and mouse.

that being said, i'm really not sure that "microing" your pet will necessarily result in a dps increase. obviously in some cases you will need to intervene because the damage boost will be so significant (raging strikes comboed with contagion is a possible example) but in other cases wasting your GCD or being locked in an instant animation is going to lower your damage.

it is really hard to say.