The clicking is strong in here.

Just key-bind things to keys that are most comfortable to you. Personally I had my movement keys set to Q(strafe left), W(forward), and E(strafe right) and do the rest with my mouse. So bind keys around that for instance 1-5 (perhaps 6 depends on your keyboard and reach, I would never bind past 6 though), R,T,A,S,D,F,G,Z,X,C,V, ect. Then you also have modifiers. I'd recommend Shift and Control giving you another 20+ keybinds, some people use Alt but I avoid it. You can also use F1-F4 for some not as urgent or out of combat skills like buffs, raise, food and what not. Also if you have the proper mouse I prefer to bind urgent skills on side buttons like silence.

For the UI set up, just try to keep it neat and near the bottom so it's out of the way. Once you've played a class for a few days and got the rotation down you shouldn't really be putting too much focus on your skill bar, only quick glances here and there to watch for cool downs or procs.