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Bind your marking signs to a hotbar and bind those hotbar buttons to your numpad, then make that hotbar hidden in the HUD Layout (You don't need hotbars to be visible in order to bind things to and access them via hotkeys).
This really helped me reduce screen clutter and I found using tab plus the numpad was easier than F1-F12.
My friend told me that he ran a group with a tank who seemed to be able to apply markings to all mobs simultaneously. Anyone know if that's possible?
Personally I prefer to use F1 etc.. buttons because that's what I've always used and it's habit.
most likely a macro that rotates thru and applies markings.
Sample that I use, works fine for me
/enemysign attack1 <t>
/wait 0.5
/nexttarget
/marking attack2 <t>
/target <attack1>
/party Attack <attack1>
its can be enhanced, but it gets complicated if you have more code than mobs.
Another option is if you have a Razor Naga mouse of G600. You can create mouse over macros. You can quickly hover over the respective mobs and use the side buttons to macro 3-5 targets in 4-5 seconds.
The above macro also works but you'll have to be quick about clicking on each mob during teh /wait times. Or, just change the macro to be /wait 1.