There's a lot to choose from in 1.22.
Hyrstmill for Hamlet Defense? DoH guild of choice for new high-level recipes? GC headquarters for new ranks/Garuda access? Market ward to camp a retainer spawn incase the search feature doesn't go as planned? Adventurer Guild for local Leve changes?
Where will you log out for your first post 1.22 activity?
I may do Hyrstmill just to check it out then get to work on GC stuff if the new ranks are needed for Garuda (Hard Mode).